Article
Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain.
Molecular pain - 24 Aug 2010
Nair Asha, Simonetti Manuela, Birsa Nicol, Ferrari Michel D, van den Maagdenberg Arn M J M, Giniatullin Rashid, Nistri Andrea, Fabbretti Elsa
Abstract excerpt
BACKGROUND: The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Ca(v)2.1), is associated with familial hemiplegic migraine-1. We investigated whether this gain-of-function mutation changed the structure and function of trigeminal neuron P2X3 receptors that are thought to be important contributors to migraine pain. RESULTS: Using in vitro trigeminal sensory...
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