Article
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.
Environmental health perspectives - 1 Dec 2002
Wan Junxiang, Shi Jinxiu, Hui Lijian, Wu Dan, Jin Xipeng, Zhao Naiqing, Huang Wei, Xia Zhaolin, Hu Gengxi
Abstract excerpt
Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lifestyle factors such...
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