Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons

6 Apr 2010

Abstract excerpt

The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that aging mice lacking DJ-1 and the GDNF-receptor Ret in the DA system display an accelerated loss of SN cell bodies,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20386724
DOI: 10.1371/journal.pbio.1000349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic NeuronsPMID 20386724Read ↗

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.Semantic proximity Read ↗

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degenerationSemantic proximity Read ↗

Role of DJ-1 in parkinson’s diseaseSemantic proximity Read ↗

Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal SystemSemantic proximity Read ↗

Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells.Semantic proximity Read ↗

Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survivalSemantic proximity Read ↗

Inactivation of <i>Drosophila</i> DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signalingSemantic proximity Read ↗

DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.Semantic proximity Read ↗

Role of DJ-1 in Parkinson's disease.Semantic proximity Read ↗

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants.Semantic proximity Read ↗

Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.Semantic proximity Read ↗

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.