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Article

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants.

The EMBO journal - 18 Feb 2014

Klein Pontus, Müller-Rischart Anne Kathrin, Motori Elisa, Schönbauer Cornelia, Schnorrer Frank, Winklhofer Konstanze F, Klein Rüdiger

Abstract excerpt

Parkinson's disease (PD)-associated Pink1 and Parkin proteins are believed to function in a common pathway controlling mitochondrial clearance and trafficking. Glial cell line-derived neurotrophic factor (GDNF) and its signaling receptor Ret are neuroprotective in toxin-based animal models of PD. However, the mechanism by which GDNF/Ret protects cells from degenerating remains unclear. We investigated whether the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24473149
DOI: 10.1002/embj.201284290
PMCID: PMC3983680

Genes

GDNF
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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