Article
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.
Gene - 1 Oct 2007
Lavara-Culebras Eusebio, Paricio Nuria
Abstract excerpt
Parkinson's disease (PD) is a progressive movement disorder caused by the selective and massive loss of dopaminergic neurons (DA) in the substantia nigra pars compacta (SNc). DJ-1 loss-of-function mutations are involved in inherited early-onset PD forms and result in dysfunction of the oxidative stress response. In mice models, DJ-1 loss provokes sensitivity to oxidative insults but does not produce...
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