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Article

Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System

13 Feb 2007

Abstract excerpt

Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration. GDNF has been tested in clinical trials for the treatment of Parkinson disease (PD), a common neurodegenerative disorder characterized by the loss of midbrain dopaminergic (DA)...

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PMID: 17298183
DOI: 10.1371/journal.pbio.0050039

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