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Article

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

29 Mar 2015

Abstract excerpt

Parkin and the glial cell line-derived neurotrophic factor (GDNF) receptor RET have both been independently linked to the dopaminergic neuron degeneration that underlies Parkinson's disease (PD). In the present study, we demonstrate that there is genetic crosstalk between parkin and the receptor tyrosine kinase RET in two different mouse models of PD. Mice lacking both parkin and RET exhibited accelerated...

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Identifiers

PMID: 25822020
DOI: 10.1172/jci79300

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