Article
DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.
Genes, brain, and behavior - 1 Apr 2010
Pham T T, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter S M, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle P J, Vogt Weisenhorn D M, Wurst W
Abstract excerpt
Loss of function of DJ-1 (PARK7) is associated with autosomal recessive early-onset Parkinson's disease (PD), one of the major age-related neurological diseases. In this study, we extended former studies on DJ-1 knockout mice by identifying subtle morphological and behavioural phenotypes. The DJ-...
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