Article
Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells.
The Journal of biological chemistry - 11 Jun 2010
Foti Rossana, Zucchelli Silvia, Biagioli Marta, Roncaglia Paola, Vilotti Sandra, Calligaris Raffaella, Krmac Helena, Girardini Javier Enrique, Del Sal Giannino, Gustincich Stefano
Abstract excerpt
Mutations in PARK7/DJ-1 are associated with autosomal recessive, early onset Parkinson disease (PD). DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. Here we show that DJ-1 plays an essential role in the expression of rearranged during transfection (RET), a receptor for the glial cell line-derived neurotrophic factor, a neuroprotective...
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