Article
Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.
Human molecular genetics - 1 Dec 2004
Hirota Takeshi, Ieiri Ichiro, Takane Hiroshi, Maegawa Shinji, Hosokawa Masakiyo, Kobayashi Kaoru, Chiba Kan, Nanba Eiji, Oshimura Mitsuo, Sato Tetsuo, Higuchi Shun, Otsubo Kenji
Abstract excerpt
The human cytochrome P450 3A4 (CYP3A4) plays a dominant role in the metabolism of numerous clinically useful drugs. Alterations in the activity or expression of this enzyme may account for a major part of the variation in drug responsiveness and toxicity. However, it is generally accepted that most of the known single nucleotide polymorphisms in the coding and 5'-flanking regions are not the main determinants for...
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