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Article

Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients.

Clinica chimica acta; international journal of clinical chemistry - 5 Jun 2013

Willrich Maria Alice V, Rodrigues Alice C, Cerda Alvaro, Genvigir Fabiana D V, Arazi Simone S, Dorea Egidio L, Bernik Marcia M S, Bertolami Marcelo C, Faludi Andre, Largura Alvaro, Baudhuin Linnea M, Bryant Sandra C, Hirata Mario Hiroyuki, Hirata Rosario Dominguez Crespo

Abstract excerpt

BACKGROUND: Variability of response to statins has been related to polymorphisms in genes involved in cholesterol homeostasis and statin metabolism, such as CYP3A4 and CYP3A5. We investigated the effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and on CYP3A activity and their interactions with common variants. METHODS: Unrelated individuals (n=121) with hypercholesterolemia (HC)...

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PMID: 23501331
DOI: 10.1016/j.cca.2013.03.007

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AGT

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