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Article

Antiviral Drug Resistance of Human Cytomegalovirus

1 Oct 2010

Abstract excerpt

The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced knowledge of the virological targets and the mechanisms of antiviral activity. The currently approved drugs, ganciclovir (GCV), foscarnet (FOS), and cidofovir (CDV), target the viral DNA polymerase. GCV anabolism also requires phosphorylation by the virus-encoded UL97 kinase. GCV resistance mutations have been identified in both...

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PMID: 20930070
DOI: 10.1128/cmr.00009-10

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