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Article

Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA.

Journal of molecular biology - 5 Sept 2008

Zhang Xin, Kung Simon, Shan Shu-ou

Abstract excerpt

Two GTPases in the signal recognition particle (SRP) and its receptor (SR) control the delivery of newly synthesized proteins to the endoplasmic reticulum or plasma membrane. During the protein targeting reaction, the 4.5S SRP RNA accelerates the association between the two GTPases by 400-fold. Using fluorescence resonance energy transfer, we demonstrate here that formation of a stable SRP x SR complex involves...

Topics

Catalysis
Endoplasmic Reticulum
Escherichia coli Proteins
Fluorescence Resonance Energy Transfer
GTP Phosphohydrolases
Mutation
RNA, Bacterial
RNA, Ribosomal
Receptors, Cytoplasmic and Nuclear
Receptors, Peptide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Recognition Particle

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Identifiers

PMID: 18617187
DOI: 10.1016/j.jmb.2008.05.049
PMCID: PMC2630804

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Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA.PMID 18617187Read ↗

Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end.Semantic proximity Read ↗

The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting.Semantic proximity Read ↗

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Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.Semantic proximity Read ↗

Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP.Semantic proximity Read ↗

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