Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA.

Journal of molecular biology - 5 Sept 2008

Zhang Xin, Kung Simon, Shan Shu-ou

Abstract excerpt

Two GTPases in the signal recognition particle (SRP) and its receptor (SR) control the delivery of newly synthesized proteins to the endoplasmic reticulum or plasma membrane. During the protein targeting reaction, the 4.5S SRP RNA accelerates the association between the two GTPases by 400-fold. Using fluorescence resonance energy transfer, we demonstrate here that formation of a stable SRP x SR complex involves...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Peptide

Share to RNA, Bacterial

Share to RNA, Ribosomal

Share to Signal Recognition Particle

Source

Open in PubMed Open full text

Identifiers

PMID: 18617187
DOI: 10.1016/j.jmb.2008.05.049
PMCID: PMC2630804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA.PMID 18617187Read ↗

Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end.Semantic proximity Read ↗

The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.Semantic proximity Read ↗

Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP.Semantic proximity Read ↗

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.Semantic proximity Read ↗

Structure of the chloroplast signal recognition particle (SRP) receptor: domain arrangement modulates SRP-receptor interaction.Semantic proximity Read ↗

Structure and Switch Cycle of SRβ as Ancestral Eukaryotic GTPase Associated with Secretory Membranes.Semantic proximity Read ↗

Molecular evolution of SRP cycle components: functional implications.Semantic proximity Read ↗

Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.