Article
FcγRIIB Gene Polymorphisms Are Associated with Disease Risk and Clinical Manifestations of Systemic Lupus Erythematosus in Koreans.
The Tohoku journal of experimental medicine - 1 Jul 2015
Jeon Ja-Young, Kim Keon-Young, Kim Bong-Sik, Jung Ju-Yang, Kim Hyoun-Ah, Suh Chang-Hee
Abstract excerpt
Systemic lupus erythematosus (SLE) is chronic autoimmune disease with various autoantibodies, which are involved in tissue damage. Fc gamma receptors (FcγRs) bind the constant region of the immunoglobulin G and transmit stimulatory or inhibitory signal to immune cells. The FcγR genes map to 1q23, a susceptible locus for SLE. We have screened single nucleotide polymorphisms (SNPs) in one of FcγR gene, FcγRIIB,...
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