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Article

Alzheimer disease models and human neuropathology: similarities and differences

15 Nov 2007

Abstract excerpt

Animal models aim to replicate the symptoms, the lesions or the cause(s) of Alzheimer disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its lesions: the extracellular deposits of Abeta peptide and the intracellular accumulation of tau protein. Mutated human APP transgenes result in the deposition of Abeta peptide, similar but not identical to the Abeta peptide of human senile...

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PMID: 18038275
DOI: 10.1007/s00401-007-0312-8

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