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The importance of continuing development of novel animal models of Alzheimer's disease and Alzheimer's disease and related dementias

26 Jun 2024

Abstract excerpt

The development of the first mouse models of Alzheimer's disease (AD) in the mid-1990s was recognized as a significant advance in the research field. These models use transgenic overexpression of single mutations in human amyloid precursor protein (APP) or presenilin 1 (PS1). The APP mutation models like the PDAPP and the Tg2576 mice developed age-related amyloid beta (Aβ) deposition, ultimately resulting in...

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PMID: 38923143
DOI: 10.1002/alz.14105

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