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Practical considerations for choosing a mouse model of Alzheimer’s disease

1 Dec 2017

Abstract excerpt

Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and neurodegeneration. Genetic mutations and risk factors have been identified that are either causal or modify the disease progression. These genetic and pathological features serve as basis for the creation and validation of mouse...

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PMID: 29273078
DOI: 10.1186/s13024-017-0231-7

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