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Article

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.

Genes & development - 1 Sept 2002

Bender Carla F, Sikes Michael L, Sullivan Ruth, Huye Leslie Erskine, Le Beau Michelle M, Roth David B, Mirzoeva Olga K, Oltz Eugene M, Petrini John H J

Abstract excerpt

Mre11, Rad50, and Nbs1 function in a protein complex that is central to the metabolism of chromosome breaks. Null mutants of each are inviable. We demonstrate here that hypomorphic Rad50 mutant mice (Rad50(S/S) mice) exhibited growth defects and cancer predisposition. Rad50(S/S) mice died with complete bone marrow depletion as a result of progressive hematopoietic stem cell failure. Similar attrition occurred in...

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Source

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Identifiers

PMID: 12208847
DOI: 10.1101/gad.1007902
PMCID: PMC186667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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