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Article

Multiple functions of MRN in end-joining pathways during isotype class switching.

Nature structural & molecular biology - 1 Aug 2009

Dinkelmann Maria, Spehalski Elizabeth, Stoneham Trina, Buis Jeffrey, Wu Yipin, Sekiguchi JoAnn M, Ferguson David O

Abstract excerpt

The Mre11-Rad50-NBS1 (MRN) complex has many roles in response to DNA double-strand breaks, but its functions in repair by nonhomologous end joining (NHEJ) pathways are poorly understood. We have investigated requirements for MRN in class switch recombination (CSR), a programmed DNA rearrangement in B lymphocytes that requires NHEJ. To this end, we have engineered mice that lack the entire MRN complex in B...

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Identifiers

PMID: 19633670
DOI: 10.1038/nsmb.1639
PMCID: PMC2721910

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Multiple functions of MRN in end-joining pathways during isotype class switching.PMID 19633670Read ↗

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