Article
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.
The Journal of experimental medicine - 9 Jul 2007
Soulas-Sprauel Pauline, Le Guyader Gwenaël, Rivera-Munoz Paola, Abramowski Vincent, Olivier-Martin Christelle, Goujet-Zalc Cécile, Charneau Pierre, de Villartay Jean-Pierre
Abstract excerpt
V(D)J recombination and immunoglobulin class switch recombination (CSR) are two somatic rearrangement mechanisms that proceed through the introduction of double-strand breaks (DSBs) in DNA. Although the DNA repair factor XRCC4 is essential for the resolution of DNA DSB during V(D)J recombination, its role in CSR has not been established. To bypass the embryonic lethality of XRCC4 deletion in mice, we developed a...
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