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Article

DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.

Expert review of clinical immunology - 1 Mar 2011

Blundred Rachel M, Stewart Grant S

Abstract excerpt

DNA double-strand break (DSB) repair is an essential cellular process required to maintain genomic integrity in the face of potentially lethal genetic damage. Failure to repair a DSB can trigger cell death, whereas misrepair of the break can lead to the generation of chromosomal translocations, which is a known causative event in the development or progression of cancer. DSBs can be induced following exposure to...

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Identifiers

PMID: 21426255
DOI: 10.1586/eci.10.93

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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