Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of VHL gene mutation in human cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Dec 2004

Kim William Y, Kaelin William G

Abstract excerpt

Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have been linked to the development of sporadic hemangioblastomas and clear-cell renal carcinomas. The VHL tumor suppressor protein (pVHL), through its oxygen-dependent polyubiquitylation of hypoxia-inducible factor (HIF), plays a central role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Carcinoma, Renal Cell
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Neoplasms

Share to Pheochromocytoma

Share to Protein Processing, Post-Translational

Share to von Hippel-Lindau Disease

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 15611513
DOI: 10.1200/JCO.2004.05.061

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of VHL gene mutation in human cancer.PMID 15611513Read ↗

Role of VHL gene mutation in human renal cell carcinoma.Semantic proximity Read ↗

The VHL tumor suppressor and HIF: insights from genetic studies in mice.Semantic proximity Read ↗

The VHL tumor suppressor: master regulator of HIF.Semantic proximity Read ↗

The von Hippel-Lindau tumor suppressor gene.Semantic proximity Read ↗

The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis.Semantic proximity Read ↗

Systemic <i>VHL</i> gene functions and the VHL diseaseSemantic proximity Read ↗

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

VHL, the story of a tumour suppressor gene.Semantic proximity Read ↗

Ubiquitin Pathway in VHL Cancer SyndromeSemantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

[From gene to disease; Von Hippel-Lindau disease].Semantic proximity Read ↗

Von Hippel–Lindau Disease: Molecular Pathological Basis, Clinical Criteria, Genetic Testing, Clinical Features of Tumors and TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.