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Article

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

19 Aug 1997

Abstract excerpt

Inheritance of an inactivated form of the VHL tumor suppressor gene predisposes patients to develop von Hippel-Lindau disease, and somatic VHL inactivation is an early genetic event leading to the development of sporadic renal cell carcinoma. The VHL gene was disrupted by targeted homologous recombination in murine embryonic stem cells, and a mouse line containing an inactivated VHL allele was generated. While...

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Share to Pregnancy and preeclampsia studies
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Identifiers

PMID: 9256442
DOI: 10.1073/pnas.94.17.9102

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Related research

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Defective placental vasculogenesis causes embryonic lethality in VHL-deficient micePMID 9256442Read ↗

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