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Article

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL

14 Dec 2010

Abstract excerpt

• von Hippel–Lindau (VHL) disease • The VHL protein, pVHL • HIF-dependent pVHL functions - Hydroxylation of HIF - HIF is a key mediator of VHL defective tumorigenesis - HIF responsive genes • HIF-independent pVHL functions - Regulation of apoptosis - Control of cell senescence - Microtubule stabilization and maintenance of the primary cilium - Regulation of extracellular matrix formation - and cell – cell...

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Identifiers

PMID: 21155973
DOI: 10.1111/j.1582-4934.2010.01238.x

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