Article
Body mass index and von Hippel-Lindau gene mutations in clear-cell renal cancer: Results of the Netherlands Cohort Study on diet and cancer.
Annals of epidemiology - 1 May 2010
Smits Kim M, Schouten Leo J, Hudak Eszter, Verhage Bas, van Dijk Boukje A C, Hulsbergen-van de Kaa Christina A, Goldbohm R Alexandra, Oosterwijk Egbert, van den Brandt Piet A
Abstract excerpt
PURPOSE: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which comprises 120,852 persons. METHODS: After 11.3 years of follow-up, 337...
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