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Article

Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma.

Scientific reports - 20 Apr 2022

van de Pol Jeroen A A, Ferronika Paranita, Westers Helga, van Engeland Manon, Terpstra Martijn M, Smits Kim M, de Lange Kim, van den Brandt Piet A, Sijmons Rolf H, Schouten Leo J, Kok Klaas

Abstract excerpt

In this study, we investigate the influence of the seven genes (VHL, PBRM1, SETD2, BAP1, KDM5C, MTOR and TP53) most frequently mutated in clear cell renal cell cancer (ccRCC) on cancer-specific survival (CSS) in the prospective Netherlands Cohort Study on diet and cancer. DNA isolated from routinely archived formalin-fixed paraffin-embedded tumour blocks from 252 incident ccRCC cases was available for targeted...

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Identifiers

PMID: 35444164
DOI: 10.1038/s41598-022-10455-x
PMCID: PMC9021193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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