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Article

Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells.

Biochemical and biophysical research communications - 30 Apr 2010

Nagai Ken-ichi, Ishii Hideshi, Miyoshi Norikatsu, Hoshino Hiromitsu, Saito Toshiyuki, Sato Tetsuya, Tomimaru Yoshito, Kobayashi Shogo, Nagano Hiroaki, Sekimoto Mitsugu, Doki Yuichiro, Mori Masaki

Abstract excerpt

BACKGROUND: We recently reported that gastrointestinal (GI) cancer cells can be reprogrammed to a pluripotent state by the ectopic expression of defined embryonic stem (ES)-like transcriptional factors. The induced pluripotent cancer (iPC) cells from GI cancer were sensitized to chemotherapeutic agents and differentiation-inducing treatment during a short-term culture, although a phenotype induced by long-term...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20381452
DOI: 10.1016/j.bbrc.2010.03.176

Genes

MYC
KLF4
KRAS
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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