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Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin

27 Oct 2005

Abstract excerpt

Embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and the malignant counterparts of embryonic stem (ES) cells derived from the inner cell mass of blastocyst-stage embryos, whether human or mouse. On prolonged culture in vitro, human ES cells acquire karyotypic changes that are also seen in human EC cells. They also 'adapt', proliferating faster and becoming easier to maintain with time in...

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PMID: 16246161
DOI: 10.1042/bst20051526

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