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Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus

8 Jul 2016

Abstract excerpt

Hepatitis B virus (HBV) is not eradicated by current antiviral therapies due to persistence of HBV covalently closed circular DNA (cccDNA) in host cells, and thus development of novel culture models for productive HBV infection is urgently needed, which will allow the study of HBV cccDNA eradication. To meet this need, we developed culture models of HBV infection using human induced pluripotent stem cell-derived...

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PMID: 27386799
DOI: 10.1038/srep29358

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