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Article

Culture adaptation of embryonic stem cells echoes germ cell malignancy

9 May 2007

Abstract excerpt

Teratocarcinomas are a subset of tumours that result from the neoplastic transformation of primordial germ cells. Such germ cell tumours (GCT) are histologically heterogeneous, reflecting a capacity for differentiation (pluripotency) of their embryonal carcinoma (EC) stem cells. However, malignant evolution of these tumours may ultimately correlate with a decrease in pluripotency, because this would tend to...

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PMID: 17488340
DOI: 10.1111/j.1365-2605.2007.00762.x

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