Article

NINJA: an inducible genetic model for creating neoantigens <i>in vivo</i>

2020-01-09

Abstract excerpt

Mouse models with inducible neoantigens have been historically difficult to generate because of leaky expression of antigens in the thymus, which causes central tolerance in developing CD8 and CD4 T cells. Attempts to resolve this problem using existing genetic tools have been unsuccessful. We developed the iNversion INducible Joined neoAntigen (NINJA) mouse model that uses RNA splicing, DNA recombination, and thr...

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Identifiers and source

Literature Corpus work: 1417fa42-c6a5-5800-86b1-b57a5f24505e
DOI: 10.1101/2020.01.09.900894

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