Article
Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD.
Thorax - 1 Jun 2018
Dicker Alison J, Crichton Megan L, Cassidy Andrew J, Brady Gill, Hapca Adrian, Tavendale Roger, Einarsson Gisli G, Furrie Elizabeth, Elborn J Stuart, Schembri Stuart, Marshall Sara E, Palmer Colin N A, Chalmers James D
Abstract excerpt
BACKGROUND: In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear. Preclinical data suggest MBL interferes with phagocytosis of Haemophilus influenzae, a key COPD pathogen. We investigated whether MBL deficiency impacted on clinical outcomes or microbiota composition in COPD....
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