Article
DNA mismatches reveal conformational penalties in protein-DNA recognition.
Nature - 1 Nov 2020
Afek Ariel, Shi Honglue, Rangadurai Atul, Sahay Harshit, Senitzki Alon, Xhani Suela, Fang Mimi, Salinas Raul, Mielko Zachery, Pufall Miles A, Poon Gregory M K, Haran Tali E, Schumacher Maria A, Al-Hashimi Hashim M, Gordân Raluca
Abstract excerpt
Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly understood1,2. Many DNA-binding proteins induce changes in the structure of the DNA outside the...
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