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Article

Observing an induced-fit mechanism during sequence-specific DNA methylation.

The Journal of biological chemistry - 1 Dec 2006

Estabrook R August, Reich Norbert

Abstract excerpt

The characterization of conformational changes that drive induced-fit mechanisms and their quantitative importance to enzyme specificity are essential for a full understanding of enzyme function. Here, we report on M.HhaI, a sequence-specific DNA cytosine C(5) methyltransferase that reorganizes a flexible loop (residues 80-100) upon binding cognate DNA as part of an induced-fit mechanism. To directly observe this...

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Identifiers

PMID: 17005571
DOI: 10.1074/jbc.M607538200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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