Article
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.
Journal of molecular biology - 26 Mar 1999
Putnam C D, Shroyer M J, Lundquist A J, Mol C D, Arvai A S, Mosbaugh D W, Tainer J A
Abstract excerpt
Uracil-DNA glycosylase (UDG), which is a critical enzyme in DNA base-excision repair that recognizes and removes uracil from DNA, is specifically and irreversably inhibited by the thermostable uracil-DNA glycosylase inhibitor protein (Ugi). A paradox for the highly specific Ugi inhibition of UDG...
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