Article
The human prostacyclin receptor from structure function to disease.
Progress in molecular biology and translational science - 1 Jan 2009
Martin Kathleen A, Gleim Scott, Elderon Larkin, Fetalvero Kristina, Hwa John
Abstract excerpt
Thirty years have passed since Vane and colleagues first described a substance, prostanoid X, from microsomal fractions (later called prostacyclin) that relaxed rather than contracted mesenteric arteries. The critical role of prostacyclin in many pathophysiological conditions, such as atherothrombosis, has only recently become appreciated (through receptor knockout mice studies, selective cyclooxygenase-2...
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