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Article

Acceleration of Cardiovascular Disease by a Dysfunctional Prostacyclin Receptor Mutation

7 Mar 2008

Abstract excerpt

Recent increased adverse cardiovascular events observed with selective cyclooxygenase-2 inhibition led to the withdrawal of rofecoxib (Vioxx) and valdecoxib (Bextra), but the mechanisms underlying these atherothrombotic events remain unclear. Prostacyclin is the major end product of cyclooxygenase-2 in vascular endothelium. Using a naturally occurring mutation in the prostacyclin receptor, we report for the first...

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Identifiers

PMID: 18323528
DOI: 10.1161/circresaha.107.165936

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