Article
Molecular analysis of Iranian colorectal cancer patients at risk for Lynch syndrome: a new molecular, clinicopathological feature.
Journal of gastrointestinal cancer - 1 Jun 2015
Zeinalian Mehrdad, Emami Mohammad Hassan, Salehi Rasoul, Naimi Azar, Kazemi Mohammad, Hashemzadeh-Chaleshtori Morteza
Abstract excerpt
PURPOSE: Microsatellite instability (MSI) and mismatch repair (MMR) gene expression present a hallmark mutational signature of Lynch syndrome as a common hereditary cancer predisposing condition. Since there is not enough data of molecular and clinicopathological aspects of the disease in Iranian populations, this article is a new description in Central Iran. METHODS: It is a descriptive analytical study in which...
Topics
- Biomarkers, Tumor
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Mismatch Repair
- Female
- Follow-Up Studies
- Germ-Line Mutation
- Humans
- Immunoenzyme Techniques
- Iran
- Male
- Microsatellite Instability
- Middle Aged