Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence of germline mutations of <i>MLH1</i> and <i>MSH2</i> in hereditary nonpolyposis colorectal cancer families from Spain

31 Jan 2002

Abstract excerpt

HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathogenic mutation lies in 1 of the 5 known DNA MMR genes (MSH2, MLH1, PMS1, PMS2 and MSH6). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Colorectal Cancer Screening and Detection
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11920650
DOI: 10.1002/ijc.10240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of germline mutations of <i>MLH1</i> and <i>MSH2</i> in hereditary nonpolyposis colorectal cancer families from SpainPMID 11920650Read ↗

Deletions Account for 17% of Pathogenic Germline Alterations in <i>MLH1</i> and <i>MSH2</i> in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) FamiliesSemantic proximity Read ↗

Spectrum and frequencies of mutations inMSH2 andMLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancerSemantic proximity Read ↗

Analysis of mismatch repair gene mutations in Turkish HNPCC patients.Semantic proximity Read ↗

MLH1 and MSH2 mutations in Colombian families with hereditary nonpolyposis colorectal cancer (Lynch syndrome)--description of four novel mutations.Semantic proximity Read ↗

Novel MLH1 and MSH2 germline mutations in the first HNPCC families identified in Slovakia.Semantic proximity Read ↗

Novel and recurrent germline alterations in the MLH1 and MSH2 genes identified in hereditary nonpolyposis colorectal cancer patients in Slovakia.Semantic proximity Read ↗

Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online.Semantic proximity Read ↗

Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes <i>MSH2</i>, <i>MLH1</i>, <i>MSH6,</i> and <i>PMS2</i> responsible for hereditary nonpolyposis colorectal cancer (HNPCC)Semantic proximity Read ↗

Ten novel MSH2 and MLH1 germline mutations in families with HNPCC.Semantic proximity Read ↗

Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database.Semantic proximity Read ↗

Spectrum of germ-line MLH1 and MSH2 mutations in Austrian patients with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.