Article
Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer.
Oncology reports - 1 Sept 2004
Caldés Trinidad, Godino Javier, Sanchez Ana, Corbacho Cesar, De la Hoya Miguel, Lopez Asenjo Jose, Saez Carmen, Sanz Julian, Benito Manuel, Ramon Y Cajal Santiago, Diaz-Rubio Eduardo
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC) represents 1-3% of all colorectal cancers. HNPCC is caused by a constitutional defect in a mismatch repair (MMR) gene, most commonly affecting the genes MLH1, MSH2 and MSH6. The MMR defect results in an increased cancer risk, with the greatest lifetime risk for colorectal cancer and other cancers associated to HNPCC. The HNPCC-associated tumor phenotype is...
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