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Article

Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Mar 2010

Guilford Parry, Humar Bostjan, Blair Vanessa

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is the only known cancer syndrome that is dominated by gastric adenocarcinoma. HDGC is caused by germline mutation of the CDH1 gene that encodes the cell adhesion protein E-cadherin. Mutation carriers have a more than 70% lifetime risk of developing DGC and an elevated risk of lobular breast cancer. Intestinal-type gastric cancer is not part of the syndrome. Clinical...

Topics

Antigens, CD
Cadherins
Carcinoma, Signet Ring Cell
Gastrectomy
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation
Humans
Penetrance
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Stomach Neoplasms

Source

Identifiers

PMID: 20373070
DOI: 10.1007/s10120-009-0531-x

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20373070-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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