IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

doi:10.1200/JCO.2009.27.3730

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Article

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2010

Marcucci Guido, Maharry Kati, Wu Yue-Zhong, Radmacher Michael D, Mrózek Krzysztof, Margeson Dean, Holland Kelsi B, Whitman Susan P, Becker Heiko, Schwind Sebastian, Metzeler Klaus H, Powell Bayard L, Carter Thomas H, Kolitz Jonathan E, Wetzler Meir, Carroll Andrew J, Baer Maria R, Caligiuri Michael A, Larson Richard A, Bloomfield Clara D

Abstract excerpt

PURPOSE To analyze the frequency and associations with prognostic markers and outcome of mutations in IDH genes encoding isocitrate dehydrogenases in adult de novo cytogenetically normal acute myeloid leukemia (CN-AML). PATIENTS AND METHODS Diagnostic bone marrow or blood samples from 358 patients were analyzed for IDH1 and IDH2 mutations by DNA polymerase chain reaction amplification/sequencing. FLT3, NPM1,...

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Identifiers

PMID: 20368543
DOI: 10.1200/JCO.2009.27.3730
PMCID: PMC2881719

Genes

IDH2
IDH1
FLT3
NPM1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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