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Article

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia.

Blood - 29 Jul 2010

Thol Felicitas, Damm Frederik, Wagner Katharina, Göhring Gudrun, Schlegelberger Brigitte, Hoelzer Dieter, Lübbert Michael, Heit Wolfgang, Kanz Lothar, Schlimok Günter, Raghavachar Aruna, Fiedler Walter, Kirchner Hartmut, Heil Gerhard, Heuser Michael, Krauter Jürgen, Ganser Arnold

Abstract excerpt

Mutations in the nicotinamide adenine dinucleotide phosphate(+)-dependent isocitrate dehydrogenase gene 2 (IDH2) have recently been found in patients with acute myeloid leukemia (AML) as well as in patients with leukemic transformation of myeloproliferative neoplasms. We analyzed 272 adult patients with cytogenetically normal AML (CN-AML) for the presence of IDH2 mutations in codons R140 and R172. IDH2 mutations...

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Source

Identifiers

PMID: 20421455
DOI: 10.1182/blood-2010-03-272146

Genes

IDH2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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