Article
Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features.
American journal of clinical pathology - 1 Jan 2011
Patel Keyur P, Ravandi Farhad, Ma Deqin, Paladugu Abhaya, Barkoh Bedia A, Medeiros L Jeffrey, Luthra Rajyalakshmi
Abstract excerpt
Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes are reported in acute myeloid leukemia (AML). We studied the frequency and the clinicopathologic features of IDH1 and IDH2 mutations in AML. Mutations in IDH1 (IDH1(R)¹³²) and IDH2 (IDH2(R)¹⁷²) were assessed by Sanger sequencing in 199 AML cases. Point mutations in IDH1(R)¹³² were detected in 12 (6.0%) of 199 cases and in IDH2(R)¹⁷² in 4 (2.0%) of...
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