Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis.

doi:10.1182/bloodadvances.2022008282

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Article

Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis.

Blood advances - 10 Oct 2023

Zarnegar-Lumley Sara, Alonzo Todd A, Gerbing Robert B, Othus Megan, Sun Zhuoxin, Ries Rhonda E, Wang Jim, Leonti Amanda, Kutny Matthew A, Ostronoff Fabiana, Radich Jerald P, Appelbaum Frederick R, Pogosova-Agadjanyan Era L, O'Dwyer Kristen, Tallman Martin S, Litzow Mark, Atallah Ehab, Cooper Todd M, Aplenc Richard A, Abdel-Wahab Omar, Gamis Alan S, Luger Selina, Erba Harry, Levine Ross, Kolb E Anders, Stirewalt Derek L, Meshinchi Soheil, Tarlock Katherine

Abstract excerpt

Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this study was to describe the prevalence, mutational profile, and prognostic significance of IDH mutations in AML across age. Our cohort included 3141 patients aged between <1 month and 88 years treated on Children's Cancer Group/Children's Oncology...

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PMID: 37267439
DOI: 10.1182/bloodadvances.2022008282
PMCID: PMC10562769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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