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Article

IDH mutations in acute myeloid leukemia.

Human pathology - 1 Oct 2012

Rakheja Dinesh, Konoplev Sergej, Medeiros L Jeffrey, Chen Weina

Abstract excerpt

Acute myeloid leukemia is a heterogeneous group of diseases. Mutations of the isocitrate dehydrogenase (IDH) genes represent a novel class of point mutations in acute myeloid leukemia. These mutations prevent oxidative decarboxylation of isocitrate to α-ketoglutarate and confer novel enzymatic activity, facilitating the reduction of α-ketoglutarate to d-2-hydroxyglutarate, a putative oncometabolite. IDH1/IDH2...

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Topics

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Share to IDH1 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 22917530
DOI: 10.1016/j.humpath.2012.05.003

Genes

IDH1
IDH2
NPM1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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