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Article

Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity

20 Jun 2012

Abstract excerpt

Phagocytes, including macrophages, recognize phosphatidylserine exposed on apoptotic cells as an "eat me" signal. Milk Fat Globule EGF Factor VIII (MFG-E8) is secreted by one subset of macrophages, whereas Tim4, a type I membrane protein, is expressed by another. These proteins bind tightly to phosphatidylserine on apoptotic cells and enhance their engulfment by macrophages. To study the contribution of these...

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PMID: 22723547
DOI: 10.1093/intimm/dxs064

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