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Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity

10 Nov 2014

Abstract excerpt

The rapid and efficient clearance of apoptotic cells results in the elimination of auto-antigens and provides a strong anti-inflammatory and immunosuppressive signal to prevent autoimmunity. While professional and non-professional phagocytes utilize a wide array of surface receptors to recognize apoptotic cells, the recognition of phosphatidylserine (PS) on apoptotic cells by PS receptors on phagocytes is the...

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Identifiers

PMID: 25426118
DOI: 10.3389/fimmu.2014.00566

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