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Article

T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2010

DeKruyff Rosemarie H, Bu Xia, Ballesteros Angela, Santiago César, Chim Yee-Ling E, Lee Hyun-Hee, Karisola Piia, Pichavant Muriel, Kaplan Gerardo G, Umetsu Dale T, Freeman Gordon J, Casasnovas José M

Abstract excerpt

T cell/transmembrane, Ig, and mucin (TIM) proteins, identified using a congenic mouse model of asthma, critically regulate innate and adaptive immunity. TIM-1 and TIM-4 are receptors for phosphatidylserine (PtdSer), exposed on the surfaces of apoptotic cells. Herein, we show with structural and b...

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Identifiers

PMID: 20083673
DOI: 10.4049/jimmunol.0903059
PMCID: PMC3128800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20083673-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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