Article
Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2005
Stuart Lynda M, Takahashi Kazue, Shi Lei, Savill John, Ezekowitz R Alan B
Abstract excerpt
Mannose-binding lectin (MBL) is a circulating serum protein that is sequestered to sites of inflammation and infection. MBL is a member of the collectin family with structural similarities to the lung collectins and functional similarities to C1q. Both MBL and C1q activate complement; C1q activates the classical pathway and MBL the lectin pathway. Here we demonstrate that MBL binds apoptotic cells in vitro and...
Topics
- Animals
- Antibodies, Antinuclear
- Antigen-Presenting Cells
- Apoptosis
- Autoimmunity
- B-Lymphocyte Subsets
- Binding Sites
- Female
- Germinal Center
- Lymphocyte Activation
- Male
- Mannose-Binding Lectin
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype